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Winkelstein JA, Marino MC, Johnston RB Jr, et al. GeneReviews ® Seattle (WA): University of Washington, Seattle 1993-2022. In: Pagon RA, Adam MP, Ardinger HH, et al, eds. *Serious infection was defined as a clinical event requiring hospitalization and intravenous antibiotics. This remains, however, largely dependent on several factors, including time of diagnosis, access to care, expertise of caregiver, adherence to therapy, and lifestyle modifications. With the development of preventative therapies and the early recognition of infectious complications, 90% of children with CGD now survive into adulthood. 1,7,12,13 ACTIMMUNE ® is the only FDA-approved biologic therapy indicated for reducing the frequency and severity of serious infections* associated with CGD. The recommended treatment paradigm consists of an antibacterial, an antifungal, and immunomodulatory therapy with ACTIMMUNE ® (Interferon gamma-1b).

American College of Allergy, Asthma & Immunology (ACAAI).

American Academy of Allergy, Asthma & Immunology (AAAAI).

To help protect patients with CGD against serious infections, the triple therapy regimen of ACTIMMUNE ® (Interferon gamma-1b), antibiotic therapy, and antifungal therapy is recommended by the 9-11:

1,7* Serious infections can be life threatening and result in long hospital stays. The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment continues, and may be minimized by bedtime administration of ACTIMMUNE.Benefits of early diagnosis and treating CGDĮarly diagnosis and prophylactic treatment is beneficial for patients with CGD because they are more susceptible to and have a higher incidence of serious infections.At doses 10 times greater than the weekly recommended dose, ACTIMMUNE may exacerbate pre-existing cardiac conditions, or may cause reversible neurological effects such as decreased mental status, gait disturbance, and dizziness.Reversible neutropenia, thrombocytopenia, and elevations of AST and/or ALT have been observed during ACTIMMUNE therapy.Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE.

Acetaminophen may be used to prevent or partially alleviate the fever and headache The most common adverse experiences occurring with ACTIMMUNE therapy are “flu-like” symptoms such as fever, headache, chills, myalgia, or fatigue, which may decrease in severity as treatment continues, and may be minimized by bedtime administration of ACTIMMUNE.Avoid simultaneous administration of ACTIMMUNE with other heterologous serum protein or immunological preparations.Concomitant use of drugs with neurotoxic, hematotoxic, or cardiotoxic effects may increase the toxicity of interferons.Long-term effects of ACTIMMUNE on fertility are not known.ACTIMMUNE or nursing should be discontinued dependent on the importance of the drug to the mother Use of ACTIMMUNE by lactating mothers is not recommended.ACTIMMUNE should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.Renal toxicity has been reported in patients receiving ACTIMMUNE Monitor renal function regularly when administering ACTIMMUNE in patients with severe renal insufficiency accumulation of interferon gamma-1b may occur with repeated administration.If severe hepatic enzyme elevations develop, ACTIMMUNE dosage should be modified Patients begun on ACTIMMUNE before age 1 year should receive monthly assessments of liver function.Myelosuppression, or receiving other potentially myelosuppressive agents consider dose reduction or discontinuation of therapy.Seizure disorders or compromised central nervous system function reduce dose or discontinue.Pre-existing cardiac conditions, including ischemia, congestive heart failure, or arrhythmia.ACTIMMUNE should be used with caution in patients with:.In patients who develop or have known hypersensitivity to interferon-gamma, E coli-derived products, or any component of the product.IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS

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